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Ambulatory continuous posterior lumbar plexus nerve blocks after hip arthroplasty: a dual-center, randomized, triple-masked, placebo-controlled trial

BACKGROUND: The authors tested the hypotheses that after hip arthroplasty, ambulation distance is increased and the time required to reach three specific readiness-for-discharge criteria is shorter with a 4-day ambulatory continuous lumbar plexus block (cLPB) than with an overnight cLPB. METHODS: A cLPB consisting of 0.2% ropivacaine was provided from surgery until the following morning. Patients were then randomly assigned either to continue ropivacaine or to be switched to normal saline. Primary endpoints included (1) time to attain three discharge criteria (adequate analgesia, independence from intravenous analgesics, and ambulation > or = 30 m) and (2) ambulatory distance in 6 min the afternoon after surgery. Patients were discharged with their cLPB and a portable infusion pump, and catheters were removed on the fourth postoperative day. RESULTS: Patients given 4 days of perineural ropivacaine (n = 24) attained all three discharge criteria in a median (25th-75th percentiles) of 29 (24-45) h, compared with 51 (42-73) h for those of the control group (n = 23; estimated ratio = 0.62; 95% confidence interval, 0.45-0.92; P = 0.011). Patients assigned to receive ropivacaine ambulated a median of 34 (9-55) m the afternoon after surgery, compared with 20 (6-46) m for those receiving normal saline (estimated ratio = 1.3; 95% confidence interval, 0.6-3.0; P = 0.42). Three falls occurred in subjects receiving ropivacaine (13%), versus none in subjects receiving normal saline. CONCLUSIONS: Compared with an overnight cLPB, a 4-day ambulatory cLPB decreases the time to reach three predefined discharge criteria by an estimated 38% after hip arthroplasty. However, the extended infusion did not increase ambulation distance to a statistically significant degree

Keywords : administration & dosage,adverse effects,Aged,Ambulatory Care,Amides,Anesthetics,Local,Arthroplasty,Arthroplasty,Replacement,Hip,drug effects,drug therapy,Female,Humans,Infusion Pumps,Infusions,Intravenous,Lumbosacral Plexus,Male,methods,Middle Aged,Nerve Block,Pain,Postoperative,Ropivacaine,Sodium Chloride,surgery,therapeutic use,Time Factors,Treatment Outcome,, Continuous,Posterior,Lumbar,Plexus,Nerve, pain relief pen

Date of Publication : 2008 Sep

Authors : Ilfeld BM;Ball ST;Gearen PF;Le LT;Mariano ER;Vandenborne K;Duncan PW;Sessler DI;Enneking FK;Shuster JJ;Theriaque DW;Meyer RS;

Organisation : Department of Anesthesiology, University of California San Diego Center for Pain Medicine, 9300 Campus Point Drive, MC 7651, La Jolla, California 92037-7651, USA. bilfeld@ucsd.edu

Journal of Publication : Anesthesiology

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/18719448

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Ambulatory continuous posterior lumbar plexus nerve blocks after hip arthroplasty a dual-center, randomized, triple-masked, placebo-controlled trial | Back clinic canary wharf

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