[Adult intramedullary gliomas].
Neurochirurgie. 2017 Nov;63(5):381-390
Authors: Campello C, Parker F, Slimani S, Le Floch A, Herbrecht A, Aghakhani N, Lacroix C, Loiseau H, Lejeune JP, Perrin G, Honnorat J, Dufour H, Chinot O, Figarella D, Bauchet L, Duffau H, Lonjon M, Labauge P, Messerer M, Daures JP, Fabbro P, Ducot B
OBJECTIVES: Intramedullary gliomas are uncommon tumors accounting for lower than four% of all major central nervous system tumors. The goals of this retrospective multicenter research have been to evaluate their pure consequence in addition to administration.
METHODS AND MATERIALS: We studied 332 sufferers from 1984 to 2011. Histopathological examination revealed 72% ependymomas (94% have been low grade tumors), 24% astrocytomas (29% have been excessive grade tumors), 2.four% blended gliomas and 1.7% oligodendrogliomas.
RESULTS: The imply age at analysis was 42.four years for ependymomas, with male predominance, versus 39.6 years for astrocytomas. Ache was the commonest preliminary presentation. In 20% of circumstances, astrocytomas have been biopsied alone, however greater than 80% of ependymomas had surgical resection. Radiotherapy and chemotherapy have been reserved for malignant tumors, particularly in the event that they have been ependymomas. The 5-year survival price was 76.eight% for astrocytomas and 94.5% for ependymomas. Histology, purposeful standing previous to surgical procedure, and tumor grade are among the many prognostic components.
CONCLUSION: Our research confirmed that surgical therapy of gliomas is nicely codified, no less than for ependymomas, however adjuvant therapy continues to play a marginal position within the administration even in astrocytomas, that are infiltrative tumors.
PMID: 28527519 [PubMed – indexed for MEDLINE]