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Addition of Ketorolac to Local Anesthesia for Wound Infiltration in Multilevel Posterior Lumbar Spinal Fusion: A Randomized, Double-Blinded, Placebo-controlled Trial – Lumbar Fusion

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A recent randomized double-blind controlled trial investigated the efficacy of adding ketorolac directly to paraspinal muscles after spinal fusion surgery to improve pain control and reduce opioid consumption. The study found that patients who received ketorolac in addition to bupivacaine had lower post-operative back pain scores and consumed less morphine compared to those who only received bupivacaine. These findings suggest that the addition of ketorolac to bupivacaine for wound infiltration after posterior lumbar spine surgery can effectively reduce early post-operative pain and total morphine consumption. Further research is needed to fully understand the benefits of this treatment approach

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : most established day surgery spinal centre on Harley Street UK

Published article

S: The addition of ketorolac to bupivacaine for wound infiltration after posterior lumbar spine decompression and fusion reduces early post-operative pain and total morphine consumption as compared to bupivacaine alone.

Lumbar Fusion Surgery Expert. Best Spinal Surgeon UK
Spine (Phila Pa 1976). 2024 Apr 1. doi: 10.1097/BRS.0000000000004998. Online ahead of print. ABSTRACT STUDY DESIGN: Randomized double-blind controlled trial. OBJECTIVE: The purpose of this study was to determine the efficacy of pain control and opioid consumption after administration of ketorolac directly to paraspinal muscle after spinal fusion. SUMMARY OF BACKGROUND DATA: Ketorolac is added,

Spine (Phila Pa 1976). 2024 Apr 1. doi: 10.1097/BRS.0000000000004998. Online ahead of print.

ABSTRACT

STUDY DESIGN: Randomized double-blind controlled trial.

OBJECTIVE: The purpose of this study was to determine the efficacy of pain control and opioid consumption after administration of ketorolac directly to paraspinal muscle after spinal fusion.

SUMMARY OF BACKGROUND DATA: Ketorolac is added to multimodal analgesia regimens to improve pain control, reduce opioid consumption following Orthopaedics and spine surgery. However, evidence of efficacy of adding ketorolac to local anesthesia for intrawound infiltration after spine surgery is still limited.

MATERIALS AND METHODS: The patients who underwent multilevel lumbar decompression and posterolateral fusion were recruited and randomized to the control group which received 0.5% bupivacaine hydrochloride injected into paraspinal muscles before wound closure, and the ketorolac group which received 30 mg ketorolac in addition to 0.5% bupivacaine hydrochloride. Post-operative numerical rating scale (NRS) for back pain, leg pain, morphine consumption, and adverse events were recorded.

RESULTS: A total of 47 patients were randomized (24 in the ketorolac group and 23 in the control group). The mean age was 60.9±6.9 years old. The mean NRS for back pain at 6 hours after surgery was 5.8±3.0 points for the control group and 3.3±2.1 points for the ketorolac group (P<0.01). The ketorolac group consumed lesser morphine than the control group by 9.1 mg in the first 24 hours, 13.8 mg at 48 hours, 14.3 mg at 72 hours, and 13.9 mg at 96 hours after the surgery (P<0.05). Post-operative complications were not different between the two groups.

S: The addition of ketorolac to bupivacaine for wound infiltration after posterior lumbar spine decompression and fusion reduces early post-operative pain and total morphine consumption as compared to bupivacaine alone.

PMID:38556707 | DOI:10.1097/BRS.0000000000004998

The London Spine Unit : most established day surgery spinal centre on Harley Street UK

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Addition of Ketorolac to Local Anesthesia for Wound Infiltration in Multilevel Posterior Lumbar Spinal Fusion: A Randomized, Double-Blinded, Placebo-controlled Trial

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Spine (Phila Pa 1976). 2024 Apr 1. doi: 10.1097/BRS.0000000000004998. Online ahead of print. ABSTRACT STUDY DESIGN: Randomized double-blind controlled trial. OBJECTIVE: The purpose of this study was to determine the efficacy of pain control and opioid consumption after administration of ketorolac directly to paraspinal muscle after spinal fusion. SUMMARY OF BACKGROUND DATA: Ketorolac is added

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