A uncommon case of metastatic extramammary Paget illness of the backbone and assessment of the literature.
J Clin Neurosci. 2017 Nov;45:161-165
Authors: Ahmed AK, Goodwin CR, Abu-Bonsrah N, Nguyen D, Sciubba DM
Extramammary Paget illness is an intraepithelial neoplasm affecting cells wealthy in apocrine glands-often positioned within the vulvar, scrotal, or perianal area. It sometimes impacts older sufferers, between the ages of 50 and 80years previous, and is most frequently restricted to the dermis. A 47-year-old Asian male first introduced with enlargement of the proper inguinal lymph node. A subsequent biopsy revealed extrammamary Paget illness of the scrotum. The affected person ultimately developed vital worsening again ache with bilateral decrease extremity numbness and weak point three months later. Imaging demonstrated a pathologic compression fracture of the L4 vertebral physique with metastatic epidural spinal twine compression. The affected person underwent surgical decompression of the backbone with bilateral L4 laminectomy, resection of epidural tumor, and pedicle screw fixation from L2 to S1. Surgical pathology demonstrated metastatic adenocarcinoma in line with extramammary Paget illness. Though two different case stories have described spinal metastases from extramammary Paget illness, to the writer’s data, this represents the primary report of surgical decompression and fusion for extramammary Paget illness of the backbone.
PMID: 28887080 [PubMed – indexed for MEDLINE]