Menu
Menu
19 Harley St, London, W1G 9QJ, UK
We are London's Top Spine Clinic

A major response to trabectedin in metastatic malignant fibrous histiocytoma of the vertebra: a case report and review of the literature.

Related Articles

A major response to trabectedin in metastatic malignant fibrous histiocytoma of the vertebra: a case report and review of the literature.

Tumori. 2013 Mar-Apr;99(2):e43-8

Authors: Sereno M, Merino M, Aguayo C, Hernández S, Gutiérrez-Gutiérrez G, Zambrana Tévar F, López-Gómez M, Gómez Raposo C, Casado-Sáenz E

Abstract
Malignant fibrous histiocytoma is an aggressive tumor, the most common soft-tissue sarcoma of adult age. It is usually located in the extremities and retroperitoneum, and very rarely there is skeletal involvement. Surgery is the preferred treatment in early disease; in advanced disease, chemotherapy is the main therapeutic strategy. We present a 25-year-old female patient diagnosed with a vertebral mass in T5 with a severely compromised spinal cord. She underwent surgical decompression and the pathological findings were consistent with malignant fibrous histiocytoma. After several surgical treatments she had pulmonary progression and was therefore started on chemotherapy. She had a very poor response to most of the administered regimens until she initiated trabectedin 1 mg/m 2 every three weeks. She showed a significant improvement with a major response of the lung metastases. This report indicates that trabectedin is an active drug in advanced, previously treated metastatic malignant fibrous histiocytoma.

PMID: 23748828 [PubMed – indexed for MEDLINE]

Share to care...

Share on facebook
Facebook
Share on twitter
Twitter
Share on pinterest
Pinterest
Share on google
Google+
Share on linkedin
LinkedIn
Share on skype
Skype

What we do...

The Harley Street Hospital

Testimonials

What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

We treat all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

What our patients say about us ......

Paraspinal atrophy

I was very impressed with the consultation and diagnosis I received at the Hospital. The treatment (injection into the spine) did help but not as

Read More »

Disc touching the Thecal Sac

My treatment was excellent. Everybody was kind and considerate. Sandra G. You May Also Like:Spinal stenosis patientCaudal Epidural and Facet Joint InjectionsPatient with a Severely

Read More »