Three-T MR Imaging of Proximal Femur Microarchitecture in Topics with and with out Fragility Fracture and Nonosteoporotic Proximal Femur Bone Mineral Density.
Radiology. 2018 05;287(2):608-619
Authors: Chang G, Rajapakse CS, Chen C, Welbeck A, Egol Ok, Regatte RR, Saha PK, Honig S
Goal To find out if Three-T magnetic resonance (MR) imaging of proximal femur microarchitecture can permit discrimination of topics with and with out fragility fracture who shouldn’t have osteoporotic proximal femur bone mineral density (BMD). Supplies and Strategies Sixty postmenopausal girls (30 with and 30 with out fragility fracture) who had BMD T scores of larger than -2.5 within the hip have been recruited. All topics underwent dual-energy x-ray absorptiometry to evaluate BMD and Three-T MR imaging of the identical hip to evaluate bone microarchitecture. World Well being Group Fracture Danger Evaluation Device (FRAX) scores have been additionally computed. We used the Mann-Whitney take a look at, receiver working traits analyses, and Spearman correlation estimates to evaluate variations between teams, discriminatory capability with parameters, and correlations amongst BMD, microarchitecture, and FRAX scores. Outcomes Sufferers with versus with out fracture confirmed a decrease trabecular plate-to-rod ratio (median, 2.41 vs four.53, respectively), decrease trabecular plate width (Zero.556 mm vs Zero.630 mm, respectively), and decrease trabecular thickness (Zero.114 mm vs Zero.126 mm) throughout the femoral neck, and better trabecular rod disruption (43.5 vs 19.Zero, respectively), greater trabecular separation (Zero.378 mm vs Zero.323 mm, respectively), and decrease trabecular quantity (Zero.158 vs Zero.192, respectively), decrease trabecular connectivity (Zero.015 vs Zero.027, respectively) and decrease trabecular plate-to-rod ratio (6.38 vs eight.09, respectively) within the larger trochanter (P < .05 for all). Trabecular plate-to-rod ratio, plate width, and thickness throughout the femoral neck (areas underneath the curve [AUCs], Zero.654-Zero.683) and trabecular rod disruption, quantity, connectivity, plate-to-rod ratio, and separation throughout the larger trochanter (AUCs, Zero.662-Zero.694) allowed discrimination of sufferers with fracture from management topics. Femoral neck, whole hip, and backbone BMD didn’t differ between and didn’t permit discrimination between teams. FRAX scores together with and never together with BMD allowed discrimination between teams (AUCs, Zero.681-Zero.773). Two-factor fashions (one MR imaging microarchitectural parameter plus a FRAX rating with out BMD) allowed discrimination between teams (AUCs, Zero.702-Zero.806). There have been no linear correlations between BMD and microarchitectural parameters (Spearman ?, -Zero.198 to Zero.196). Conclusion Three-T MR imaging of proximal femur microarchitecture permits discrimination between topics with and with out fragility fracture who’ve BMD T scores of larger than -2.5 and will present totally different details about bone high quality than that offered by dual-energy x-ray absorptiometry. © RSNA, 2018.
PMID: 29457963 [PubMed – indexed for MEDLINE]