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Day: February 4, 2019

The influence of selected demographic factors and wound location on the concentration of vascular endothelial growth factor (VEGF-A) in the wound healing process after neurosurgery: brief report.

By London Spine
Related Articles

The influence of selected demographic factors and wound location on the concentration of vascular endothelial growth factor (VEGF-A) in the wound healing process after neurosurgery: brief report.

Wound Repair Regen. 2012 Sep-Oct;20(5):667-75

Authors: Slusarz R, Gadomska G, Biercewicz M, Grzelak L, Szewczyk MT, Rość D, Beuth W

Abstract
The main aim of the work was to estimate the influence of selected demographic factors and wound location on the concentration of the vascular endothelial growth factor (VEGF-A) in patients after neurosurgical operations. The study included 20 adult patients who received a surgical treatment because of degenerative spine changes. Measurements of the concentration of the VEGF-A in the patients’ blood serum were taken three times (the first time–before the operation; the second time–during the first 24 hours after surgery; and the third time–between the fifth and the seventh day after the operation). No statistically significant correlation between the concentration of VEGF-A in the patients’ blood serum before and after the operation was noted. A statistically significant correlation between the concentration of VEGF-A in the individual measurements was found. It can be concluded that people with a higher concentration of VEGF-A before surgery obtained a higher concentration of VEGF-A in the measurements taken after the operation. There is a statistically significant link between the patient’s age and the concentration of VEGF-A during the immediate postoperative period (the older the patient, the higher the level of VEGF-A is observed).

PMID: 22985038 [PubMed – indexed for MEDLINE]

Depression, anxiety and quality of life in caregiver spouses of veterans with chronic spinal cord injury.

By London Spine

Depression, anxiety and quality of life in caregiver spouses of veterans with chronic spinal cord injury.

Iran J Psychiatry. 2014 Jul;9(3):133-6

Authors: Ebrahimzadeh MH, Shojaee BS, Golhasani-Keshtan F, Moharari F, Kachooei AR, Fattahi AS

Abstract
OBJECTIVE: We were curious about the degree of anxiety and depression and their effect on the quality of life of the caregivers of veterans with spinal cord injury (SCI).
METHODS: A convenience sample of 72 out of 120 caregiver spouses of veterans with spinal cord injury participated in our study. The Hospital Anxiety and Depression Scale (HADS) were considered as a measure of depression and anxiety. The World Health Organization Quality of Life BREF questionnaire (WHOQOL-BREF) was considered to evaluate the quality of life. To compare the caregivers, we enrolled 74 matched caregiver spouses of patients without spinal cord injury.
RESULTS: The average age of the spouses was 44.7±6.5. The average time elapsed from the injury was 26.4±3.1 years. There was a significant difference in all domains of quality of life and depression between the caregivers and the control group, but there was not a significant difference in terms of anxiety. There was a negative correlation between depression and age, level of education and quality of life.
CONCLUSION: Mental care support should be implemented for veterans and their spouses in addition to the provided facilities.

PMID: 25561952 [PubMed]

Frequency of tetrazepam prescription: estimates for Germany.

By London Spine
Related Articles

Frequency of tetrazepam prescription: estimates for Germany.

Pharmacoepidemiol Drug Saf. 2014 Jun 21;

Authors: Kuepper-Nybelen J, Thuermann P, Schubert I

Abstract
PURPOSE: Authorisation was suspended on 1 August 2013 for tetrazepam-containing medicines. The aim of the study was to assess relevance and pattern of tetrazepam use by estimating the prevalence of prescribing and to analyse prescribing indications and duration. This information is needed to generate baseline data for further evaluation of prescribing muscle relaxants.
METHODS: Claims data analysis (Health Insurance Sample AOK Hesse/KV Hesse, 18.75% random sample of insurants from AOK Hesse, Germany). Study population: 267 787 insurants continuously insured or deceased in 2011. Prevalence estimates were standardised to the German population. To assess the quantity of prescribed tetrazepam, we applied defined daily dose (DDD) methodology with 125 mg of tetrazepam as 1 DDD. The prescribing indications were analysed with a matched case-control design.
RESULTS: In 2011, 2.6% of the study population received at least one tetrazepam prescription (men, 2.1%; women, 3.0%). The mean prescribed dosage was 15 DDD and increased by age up to 43 DDD in women and 30 DDD in men ≥80 years. The most frequently documented diagnoses were low-back pain (21.3%) and cervicalgia (20.3%). It appeared that the greatest difference in prevalence between tetrazepam recipients and controls was for the diagnosis ‘Other specified disorders of muscle’ (ICD: M62.8). This diagnosis was five times more prevalent in tetrazepam recipients than in controls.
CONCLUSION: Tetrazepam was the most widely prescribed muscle relaxant in Germany, hence physicians may seek an alternative after its market withdrawal. However, according to treatment guidelines, muscle relaxants play only a minor role and a multimodal approach should be preferred. Copyright © 2014 John Wiley & Sons, Ltd.

PMID: 24953211 [PubMed – as supplied by publisher]