Menu
Menu
19 Harley St, London, W1G 9QJ, UK

Day: November 11, 2017

[Unilateral pedicle screw fixation through the pedicle of fractured vertebra in combination with the short segment of pedicle screw in the treatment of thoracolumbar fracture of mild to moderate instability].

By wp_zaman
Related Articles

[Unilateral pedicle screw fixation through the pedicle of fractured vertebra in combination with the short segment of pedicle screw in the treatment of thoracolumbar fracture of mild to moderate instability].

Zhonghua Wai Ke Za Zhi. 2012 Mar;50(3):234-7

Authors: Zeng ZL, Cheng LM, Qian L, Jia YW, Yu Y, Wang JJ

Abstract
OBJECTIVE: To evaluate the efficacy of unilateral pedicle screw fixation through the pedicle of fractured vertebra in combination with the short segment of pedicle screw in the treatment of thoracolumbar fracture of mild to moderate instability.
METHODS: Twenty-six patients with single segment thoracolumbar fracture received unilateral pedicle screw fixation through the pedicle of fractured vertebra in combination with the short segment of pedicle screw from January 2008 to December 2009. There were 16 patients were male and 10 were female with an average age of 47.3 years (range from 39 to 60 years). Fracture severity score was constructed by using the load-sharing classification (4 points for 2 cases, 5 points for 14 cases, 6 points for 10 cases). By Frankel assessment system, 2 cases were in grade C, 3 in grade D, 21 in grade E. The assessment included anterior vertebral body height, the sagittal Cobb angle, the restoration of nervous function, visual analogue score (VAS) and Oswestry disability index (ODI).
RESULTS: The follow-up after the surgery was 13 – 26 months, with an average of 18.6 months. There were no fixation failure, defined as implant failure or ≥ 10° correction loss. The neurological status of 4 patients, who had an associated neurologic deficit preoperatively, was completely recovered. The Frankel grade of another case was re-rated D from the original C. The mean anterior vertebral body height increased from 57.0% ± 6.3% before the surgery to 93.1% ± 1.7% at the last follow-up(F = 455.276, P < 0.05). The sagittal Cobb angle decreased from 15.6° ± 4.7° before the surgery to 2.6° ± 5.2° at the last follow-up (F = 34.623, P < 0.05). VAS and ODI were 1.0 ± 0.7 and 17.0 ± 5.9 at the last follow-up.
CONCLUSION: Unilateral pedicle screw fixation through the pedicle of fractured vertebra combined with the short segment of pedicle screw is effective for thoracolumbar fracture with mild to moderate instability.

PMID: 22800747 [PubMed – indexed for MEDLINE]

Can neck exercises enhance the activation of the semispinalis cervicis relative to the splenius capitis at specific spinal levels?

By wp_zaman
Related Articles

Can neck exercises enhance the activation of the semispinalis cervicis relative to the splenius capitis at specific spinal levels?

Man Ther. 2015 Oct;20(5):694-702

Authors: Schomacher J, Erlenwein J, Dieterich A, Petzke F, Falla D

Abstract
The deep cervical extensor, semispinalis cervicis, displays changes in behaviour and structure in people with chronic neck pain yet there is limited knowledge on how activation of this muscle can be emphasized during training. Using intramuscular electromyography (EMG), this study investigated the activity of the deep semispinalis cervicis and the superficial splenius capitis muscle at two spinal levels (C2 and C5) in ten healthy volunteers during a series of neck exercises: 1. Traction and compression, 2. Resistance applied in either flexion or extension at the occiput, at the level of the vertebral arch of C1 and of C4, and 3. Maintaining the neck in neutral while inclined on the elbows, with and without resistance at C4. The ratio between semispinalis cervicis and the splenius capitis EMG amplitude was quantified as an indication of whether the exercise could emphasize the activation of the semispinalis cervicis muscle relative to the splenius capitis. Manual resistance applied in extension over the vertebral arch emphasized the activation of the semispinalis cervicis relative to the splenius capitis at the spinal level directly caudal to the site of resistance (ratio: 2.0 ± 1.1 measured at C5 with resistance at C4 and 2.1 ± 1.2 measured at C2 with resistance at C1). This study confirmed the possibility of emphasizing the activation of the semispinalis cervicis relative to the splenius capitis which may be relevant for targeted exercise interventions for this deep extensor muscle. Further studies are required to investigate the clinical efficacy of these exercises for people with neck pain.

PMID: 25935795 [PubMed – indexed for MEDLINE]

Genetic Targeting of Protease Activated Receptor 2 Reduces Inflammatory Astrogliosis and Improves Recovery of Function after Spinal Cord Injury.

By wp_zaman
Related Articles

Genetic Targeting of Protease Activated Receptor 2 Reduces Inflammatory Astrogliosis and Improves Recovery of Function after Spinal Cord Injury.

Neurobiol Dis. 2015 Aug 24;

Authors: Radulovic M, Yoon H, Wu J, Mustafa K, Fehlings MG, Scarisbrick IA

Abstract
Inflammatory-astrogliosis exacerbates damage in the injured spinal cord and limits repair. Here we identify Protease Activated Receptor 2 (PAR2) as an essential regulator of these events with mice lacking the PAR2 gene showing greater improvements in motor coordination and strength after compression-spinal cord injury (SCI) compared to wild type littermates. Molecular profiling of the injury epicenter, and spinal segments above and below, demonstrated mice lacking PAR2 had significantly attenuated elevations in key hallmarks of astrogliosis (glial fibrillary acidic protein (GFAP), vimentin and neurocan) and in expression of pro-inflammatory cytokines (interleukin-6 (IL-6), tumor necrosis factor (TNF) and interleukin -1 beta (IL-1β)). SCI in PAR2-/- mice was also accompanied by improved preservation of protein kinase C gamma (PKCγ)-immunopositive corticospinal axons and reductions in GFAP-immunoreactivity, expression of the pro-apoptotic marker BCL2-interacting mediator of cell death (BIM), and in signal transducer and activator of transcription 3 (STAT3). The potential mechanistic link between PAR2, STAT3 and astrogliosis was further investigated in primary astrocytes to reveal that the SCI-related serine protease, neurosin (kallikrein 6) promotes IL-6 secretion in a PAR2 and STAT3-dependent manner. Data point to a signaling circuit in primary astrocytes in which neurosin signaling at PAR2 promotes IL-6 secretion and canonical STAT3 signaling. IL-6 promotes expression of GFAP, vimentin, additional IL-6 and robust increases in both neurosin and PAR2, thereby driving the PAR2-signaling circuit forward. Given the significant reductions in astrogliosis and inflammation as well as superior neuromotor recovery observed in PAR2 knockout mice after SCI, we suggest this receptor and its agonists represent new drug targets to foster neuromotor recovery.

PMID: 26316358 [PubMed – as supplied by publisher]

Muskulär pseudo­hypertrofi yttrade sig som mjukdels­tumör – Denervering av tensor fasciae latae visade sig vara orsaken.

By wp_zaman
Related Articles

Muskulär pseudo­hypertrofi yttrade sig som mjukdels­tumör – Denervering av tensor fasciae latae visade sig vara orsaken.

Lakartidningen. 2017 Feb 03;114:

Authors: Damm H, Bruun Lauritzen J, Løvendahl Jørgensen H

Abstract
Pseudohypertrophy of musculus tensor fascia lata presenting as a soft tissue tumor: a case report Conditions presenting as palpable soft tissue masses are a common clinical issue. This case report describes a patient with unilateral pseudohypertrophy of m. tensor fasciae latae, which is an uncommon differential diagnosis for a palpable soft tissue mass. The patient presented a palpable soft tissue mass located proximally and anteriorly on the right thigh. The primary concern was a sarcoma. The patient was examined with magnetic resonance imaging and electromyography and it could be concluded that the patient had pseudohypertrophy, i.e. accumulation of excess fat and connective tissue inside m. tensor fasciae lata which was caused by impaired function of the efferent nerve at the spinal level. If the diagnosis of soft tissue masses cannot be revealed with thorough clinical history and examination, magnetic resonance imaging is recommended for further investigation.

PMID: 28170062 [PubMed – in process]

Minimal access to the posterolateral lumbar spine.

By wp_zaman

Related Articles Minimal access to the posterolateral lumbar spine. J Neurosurg Sci. 2012 Jun;56(2):97-103 Authors: Hnenny L, Fourney DR Abstract The purported advantages of minimally invasive spine surgery over open microsurgical alternatives for lumbar decompression and fusion are attractive to patients, surgeons, and hospital administrators. Shorter hospital length of stay, less blood loss, shorter operating…

Spontaneous subscapular haematoma in a patient using warfarin therapy.

By wp_zaman
Related Articles

Spontaneous subscapular haematoma in a patient using warfarin therapy.

BMJ Case Rep. 2013;2013

Authors: Cebicci H, Gurbuz S, Gunay N, Vural A

Abstract
Warfarin is widely used. Spontaneous bleeding is one of the complications of warfarin treatment. A 70-year-old man was admitted to the emergency room with right back pain. There was no history of trauma. He was using warfarin following a bypass graft. The patient’s vital signs were stable. On physical examination, swelling at the level of the right scapula was detected. Laboratory findings showed that the international normalised ratio (INR) was ↑↑ (a very high reading) (1.47 1 month previously). There was no melena on rectal examination. A chest CT was performed to differentiate the swelling of the right scapula. Warfarin was stopped and vitamin K was administered. Fresh frozen plasma was initiated and the patient was hospitalised to the cardiovascular surgical service. The fact that use of warfarin in the elderly may increase the risk of spontaneous bleeding should be especially kept in mind.

PMID: 24248312 [PubMed – in process]